Organoids that model the fetal placenta
نویسندگان
چکیده
منابع مشابه
Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain.
Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown. We compared epigenomic and regulatory features in cerebral organoids and human fetal brain, using genome-wide, base resolution DNA methylome and transcripto...
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BACKGROUND To investigate mechanisms of fetal-maternal cell interactions in the bovine placenta, we developed a model of transgenic enhanced Green Fluorescent Protein (t-eGFP) expressing bovine embryos produced by nuclear transfer (NT) to assess the distribution of fetal-derived products in the bovine placenta. In addition, we searched for male specific DNA in the blood of females carrying in v...
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Rudolf Cardinal, 22/24 Nov 1998 Implantation and the decidual response • Implantation in humans and some other species is invasive – the uterine surface epithelium is breached and the underlying stroma is invaded. (In yet other species, the epithelium remains intact with the fetal and maternal epithelia in close contact.) • The blastocyst makes a signal (unknown) which induces a stromal respons...
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Almost all water that enters the conceptus of the sheep enters via the placenta. The forces that drive water are hydrostatic and osmotic. The placental channels that allow water to cross into the fetus have not been identified by microanatomic means. Although an "equivalent pore" system can account for the diffusional entry of small hydrophilic solutes, it can be calculated that the filtration ...
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Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revolutionised colorectal cancer research and enabled an array of new experimental techniques. This 3D system models the physiology, shape, dynamics and cell make-up...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2019
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-019-0319-9